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KMID : 0378019620050080075
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New Medical Journal
1962 Volume.5 No. 8 p.75 ~ p.86
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Experimental Studies of a Pressor Substance Occurring in The Acute Toxemia of Pregnancy.
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Abstract
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In 1960 Hunter and Howard demonstrated the presence of a new pressor substance in the decidua, amniotic fluid and plasma of patients with acute toxemia, suggested the term "Hysterotonin" and obtained the conclusion as follows:
The substance, hysterotonin, seems to be a polypeptide and differs from any previously described one. The author of this paper has carried out systemical pharmacophysiological experiments amining to follow up the evidence of the pressor substance and obtained the following conclusion:
1. Decidual extract and amniotic fluid of patients with acute toxemia elevated markedly B. P. among uretane anesthesized rabbits, but failed to substatiate this effect after the decidual extract and amniotic fluid was incubated with the same amount of the kidney or liver extract of fresh rabbits or with proteolytic enzyme (pepsin, trypsin, chymotrypsin.).
2. Administration of the positive decidual extract and amniotic fluid gave rise to acceleration of the cardiac pulsation among situ rabbits and frogs, while it gave rise to slightly accelerated respiration following temporary inhibition. Administration of boiled positive amniotic fluid produced the accelerated cardiac pulsation and respiration in both nephrectomized and vagotomized rabbits.
3. When treated by Ldwen-Trendelenburg method, positive amniotic fluid and decidual extract possessed vasoconstrictive action upon vessels of isolated rabbit´s ears, kidneys and upon vessels of hind legs of male frogs, while normotensive(normal, negative.)fluid did not effect upon blood vessels of the same materials.
4. Antidiuretic action could be ascribed to the positive amniotic fluid but not to the normotensive one.
5. The positive amniotic fluid and decidual extract accomplished inhibitory action upon the movement of isolated intestinal muscle strip of the rabbit. The inhibitory action, however, evanesced completely when the extract was incubated with the same amount of the extract of cut part of the kidney or the liver of the rabbit, and did not evanesced when the extract was incubated with extract of the brain, heart, lung, spleen, small intestine, uterus or muscle of the rabbit. The action was not affected by boiling the extract.
6. Oxytocic effect of the positive amniotic fluid could be readily observed upon the isolated uterine muscle strip of the rabbit, where as the normotensive amniotic fluid was observed inactive, the oxytocic effect of the extract could not be blocked or weakened by an adrenergic blocking agent, dibenamine
By these experimental results the author assumes that presenting in high concentration in the decidua. and amniotic fluid of toxemia pregnancy, the pressor substance is a thermostable and high molecule compounb which may act the leading role in the pathophysiologic change, vasoconstriction and hypertension of toxemia pregancy.
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